Sr. Scientist II HMAP - US, Silver Spring, MD- Office-based

ICON plc is a world-leading healthcare intelligence and clinical research organization. We’re proud to foster an inclusive environment driving innovation and excellence, and we welcome you to join us on our mission to shape the future of clinical development.

We are currently seeking a Senior Research Scientist to join our diverse and dynamic team. We are seeking a Sr. Scientist II-HMAP to join a dynamic and growing team at the Walter Reed Army Institute of Research (WRAIR) Wound Infection Department (WID). WID is tasked with delivering specific, effective countermeasures for infection of combat wounds pre-injury, at the point-of-injury, and post-injury. The Human Monoclonal Antibody Platform (HMAP) group focuses on in vitro and in vivo research of virulence factors associated with ESKAPEE pathogens and developing monoclonal antibodies against them.

What You Will Be Doing:

• Select and develop relevant antigens through cell cloning and bioassay techniques.

• Apply microbiology, molecular, and cell biology techniques to generate monoclonal antibodies.

• Lead the antibody discovery and optimization team to apply translational immunology and other preclinical assays to support pipeline program progression for microbial pathogens of military relevance, including ESKAPEE pathogens.

• Develop and conduct screening tests including ELISA, flow cytometry, and cell-based assays such as opsonophagocytosis and complement activation for antibody characterization.

• Perform screening and other immunological assays for the development of vaccines and the characterization of monoclonal antibodies for antibacterial therapies.

• Perform all aspects of antibody development including screening and characterization, assay design, and preclinical development using small animal models of infection.

• Independently design experiments, make detailed observations, analyze data, interpret results, and deliver timely results.

• Communicate research findings to stakeholders, enterprise clients, collaborators, the scientific community, and the general public as well as by drafting and coordinating patents, grants, manuscripts, periodic and special reports, and other relevant reports (e.g., MIC results) routinely.

• Prepare and manage research proposals to NIH and other relevant funding agencies.

• Mentor and supervise junior scientists within the team as needed.

Your Profile:

• Citizenship: Must be a US citizen.

• Clearance: Ability to obtain NACI.

• Education: Ph.D. in a relevant field such as Microbiology, Immunology, Physiology, Molecular Biology, or Biochemistry.

• Years’ Experience: 3-5 years of experience with antibody discovery, development, and characterization.

• Proven track record of publishing in peer-reviewed journals and securing competitive funding from grants/proposals written and submitted (at least 1). (Required)

• Strong computer skills and experience with relevant software including MS Office and GraphPad Prism. (Required)

• Experience with microbiology of Gram-negative species, antibacterial development, genetics and molecular cloning to determine and develop target antigens, eukaryotic cell culture, expression vector design, transient transfection, recombinant antibody testing and development, protein expression. (ESKAPEE Pathogenes)(Required)

• Ability to establish and validate new antibody-based functional assays and characterization processes for any given pathogen is desired. (Preferred)

• Must be a strong problem solver, decision maker, and communicator.

• Proven leadership experience, with ability to multitask and delegate when needed.

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well-being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements

• A range of health insurance offerings to suit you and your family’s needs.

• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.

• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family’s well-being.

• Life assurance

• Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site (https://careers.iconplc.com/benefits) to read more about the benefits ICON offers.

ICON, including subsidiaries, is an equal opportunity and inclusive employer and is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here (https://careers.iconplc.com/reasonable-accommodations)

Interested in the role, but unsure if you meet all of the requirements? We would encourage you to apply regardless – there’s every chance you’re exactly what we’re looking for here at ICON whether it is for this or other roles.

Are you a current ICON Employee? Please click here (https://wd3.myworkday.com/icon/d/task/1422$1235.htmld) to apply