Job Information
J&J Family of Companies Postdoctoral Fellow- Oncology Discovery in Spring House, Pennsylvania
Postdoctoral Fellow- Oncology Discovery - 2406178016W
Description
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/.
The Post-doctoral Research Scientist-Oncology Discovery Hematological Malignancies [focused on Multiple Myeloma (MM)] will work independently on a project designed to further the understanding of MM and hematological malignancy biology with the goal of investigating mechanisms of T cell engager resistance. You will have the ability to work with and learn from experts within discovery oncology research, specialized in cell and molecular biology, flow cytometry, computational biology, and in vivo sciences, while also leveraging additional resources at J&J Innovative Medicine. The length of the position will be 2 years, the candidate is expected to present and publish their research.
In this role you will:
Work with discovery scientists within J&J Innovative Medicine to design and execute studies to further our understanding of mechanisms of resistance to T cell redirection therapeutics (ie. Bispecific/multispecific antibodies and CART), with a focus on the multiple myeloma (MM) disease area
Integrate internal and external data in the design and interpretation of experiments
Develop and utilize assays to mimic bone marrow-like conditions
Investigate MM protein biology
Use CRISPR/Cas9 screening technologies
Design and analyze multi-color (6-16) flow cytometry experiments to characterize immune cell function (e.g., celesta, fortessa, symphony)
Perform advanced molecular and cellular biology techniques (e.g., viral and non-viral cell transduction, Western blot, DNA/RNA isolation, and qRT-PCR)
Perform functional T cell redirection assays using bispecific/multispecific antibodies and CART cell therapy
Maintain detailed and organized experimental records and stay compliant on all relevant internal and external training requirements
Communicate scientific results to multidisciplinary teams including computational biologists, bench scientists, clinicians, and management in an appropriate biological context
Qualifications
A Ph.D. in cell and/or molecular biology, oncology, immunology, biochemistry, microbiology, or related field received in the last 0-3 years or by the start of this position.
Expertise in the oncology area - including tumor biology, signaling, immuno-oncology, T cell redirection (antibody or cell therapy).
MM biology and T cell engagement experience is preferred but not necessary
Basic understanding of bioinformatics and/or RNA sequencing is preferred but not necessary
Strong publication record demonstrating relevant experience
Strong communication AND collaboration skills required with a One-Team focused approach
Must be legally authorized to work in the U.S. for the full duration of the role
The base pay for this position is $95,000/year, this position is eligible for a sign-on bonus. This position is eligible for a sign-on and/or early incentive bonus. This is a duration based role with eligibility for severance.
The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis.
Benefits:
Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance.
Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
This position is eligible to participate in the Company’s long-term incentive program.
Employees are eligible for the following time off benefits:
Vacation – up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year
Holiday pay, including Floating Holidays – up to 13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits
This job posting is anticipated to close on May 13th, 2024. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications.
Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
#JNJPostDoc
Primary Location NA-US-Pennsylvania-Spring House
Organization Janssen Research & Development, LLC (6084)
Relocation Eligible: No
Job Function Post Doc - Drug Discovery & Pre-Clinical/Clinical Development
Req ID: 2406178016W
J&J Family of Companies
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