University of Pennsylvania RESEARCH SPECIALIST B, PROCESS DEVELOPMENT in Philadelphia, Pennsylvania
RESEARCH SPECIALIST B, PROCESS DEVELOPMENT Below you will find the details for the position including any supplementary documentation and questions you should review before applying for the opening. To apply for the position, please click the Apply for this Job link/button.
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Reference Number 40-30733
Posted Job Title RESEARCH SPECIALIST B, PROCESS DEVELOPMENT
School Name Perelman School of Medicine
Org DM-Gene Therapy Program
Posted to the Web 01/10/2019
Posted Job/Salary Grade 025
Employment Type Exempt
Position Type Full Time
Position Schedule 8:00 - 5:00
Position Length Contingent Upon Funding
Position End Date
The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn’s distinctive interdisciplinary approach to scholarship and learning.
Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.
The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.
The Perelman School of Medicine at the University of Pennsylvania is the oldest and one of the finest medical schools in the United States. Penn is rich in tradition and heritage and at the same time consistently at the forefront of new developments and innovations in medical education and research. Since its founding in 1765 the School has been a strong presence in the community and prides itself on educating the leaders of tomorrow in patient care, biomedical research, and medical education. http://www.med.upenn.edu/
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the ‘go-to’ organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.Due to significant growth, we are looking for a new, Research Specialist, Process Development (RSPD) to provide support to Senior Process Development Scientists to design, optimization and scale-up of mammalian cell culture processes suitable for cGMP manufacturing of AAV vectors. As an RSPD, you will perform all upstream cell culture activities ranging from cell seeding, media development and optimization, cell line development, and bioreactor operation. You will investigate and compare scalable AAV production systems, perform laboratory experiments including DOE studies, process validation, process range, robustness, and troubleshooting studies. You will be involved in the development and use of in-process assays to monitor critical quality attributes. Also, you will be responsible for the ordering of supplies for PD activities.You will work both independently and as part of a team to accomplish project goals within specified timelines and will participate in technology transfer processes both to internal production groups and contracted manufacturers.
BS in Biochemistry, Biology, or related disciplines and 1-3 years of relevant experience, or an equivalent combination of education and experience, are required.Previous experience working with Process Development or Process Optimization strongly preferredMust have strong technical experience with mammalian cell culture, including cell seeding, media optimization, or cell line developmentExperience working with bioreactors strongly preferredMust be highly motivated, have excellent organizational, communication and interpersonal skills.Must be able to work independently and as part of a multi-disciplinary team.
Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Quick Link http://jobs.hr.upenn.edu/postings/42717
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