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Mount Sinai Health System Postdoctoral Fellow-MSH in New York, New York

Job Description

Strength Through Diversity

Ground breaking science. Advancing medicine. Healing made personal.

Roles & Responsibilities:

The Mullins Lab at the Icahn School of Medicine at Mount Sinai is seeking a Postdoctoral Fellow with a PhD in Statistical Genetics, Computational Biology or a similar field, to lead statistical genetic studies of suicide phenotypes. The International Suicide Genetics Consortium (ISGC) is the world’s largest resource for conducting genetic studies of suicidality, and aims to elucidate the genetic etiology of suicide outcomes through large-scale genome-wide association studies (GWAS). A Postdoctoral Fellow will have the opportunity to lead forthcoming analyses by the ISGC including: GWAS of >68,000 suicide attempt cases, >18,000 suicide death cases, and >175,000 suicidal ideation cases, characterization of the shared and distinct genetic architectures of suicide outcomes, elucidation of genetic heterogeneity within suicide outcomes with respect to sex and ancestry, identification of biologically relevant pathways, tissues and cell-types, and exploration of potential causal relationships with modifiable risk factors. The Postdoctoral Fellow will also work on a related initiative in the Mullins Lab, to develop clinical and genetic risk prediction models for suicide outcomes in electronic health record-linked biobanks. This will involve applying natural language processing algorithms to physician notes, and training genetic risk predictors based on ISGC studies, in the Mount Sinai BioMe biobank of 54,000 individuals.

Recent relevant work:

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors (https://pubmed.ncbi.nlm.nih.gov/34861974/)

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents (https://pubmed.ncbi.nlm.nih.gov/32998551/)

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

The Postdoctoral Fellow will work under the supervision of Dr. Niamh Mullins, Assistant Professor in the Department of Psychiatry, the Mount Sinai Clinical Intelligence Institute, and the Department of Genetics and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai. The Postdoctoral Fellow will spend approximately 75% and 25% of their time on the ISGC and risk prediction projects respectively. Responsibilities will include statistical analysis of genetic and genomic datasets and electronic health records, manuscript writing, oral presentations at lab meetings, consortium calls, and scientific conferences, and engaging in regular collaborative meetings with teams of scientists locally and internationally.

Environment:

The Mount Sinai Health System encompasses the Icahn School of Medicine at Mount Sinai (https://icahn.mssm.edu/) and eight hospital campuses in the New York metropolitan area, and is internationally acclaimed for its excellence in research, patient care, and education across a range of specialties. The Icahn School of Medicine is located on Mount Sinai’s main campus next to Central Park in the Upper East Side of Manhattan. The Mullins Lab is part of the Department of Psychiatry (https://icahn.mssm.edu/about/departments/psychiatry) , the Mount Sinai Clinical Intelligence Institute (MSCII) (https://icahn.mssm.edu/research/clinical-intelligence-center) , and the Department of Genetics and Genomic Sciences (https://icahn.mssm.edu/research/genomics) . The lab conducts genomic studies of psychiatric disorders to identify genetic associations, prioritize likely causal genes or variants and their functional consequences, uncover relevant tissues, cell-types, pathways and potential therapeutic targets, and develop genetic risk predictors. We are key contributors to the International Suicide Genetics Consortium, and the Psychiatric Genomics Consortium (https://www.med.unc.edu/pgc/) , and we collaborate widely with labs at Mount Sinai and other institutes. Through the Mount Sinai hospital system, the lab has access to electronic health records of over 5 million patients for research, 54,000 of whom have genetic data available through the BioMe biobank (https://icahn.mssm.edu/research/ipm/programs/biome-biobank) . We provide a vibrant work environment, with access to large-scale genomic datasets, high performance scientific computing facilities, seminar series, training workshops, local, national, and international conferences, funding opportunities, and mentorship resources. The Mullins Lab is committed to fostering a culture that is welcoming and inclusive to diverse groups of individuals, and is passionate about supporting the development of team members scientifically and professionally.

Requirements:

Eligibility:

  • PhD in Statistical Genetics, Biostatistics, Computational Biology, Bioinformatics or similar field

  • Programming skills (particularly R, Unix/ Linux)

  • Experience working with genetic datasets

  • Proficiency in running statistical genetics software

  • Excellent written and oral communication skills in English

  • Ability to work independently and as part of a collaborative international team

Desired:

  • Working knowledge of GWAS and post-GWAS analyses

  • Experience with diverse ancestry genetic data

  • Familiarity with psychiatric nosology

Starting date: This position is available immediately

Duration: Initial appointment for two years with opportunity for extension

Benefits: This opportunity comes with competitive salary. The Icahn School of Medicine at Mount Sinai offers visa sponsorship, medical benefits, subsidized child care resources, and subsidized apartment rentals in Manhattan to Postdoctoral Fellows and their families.

Apply: Please send the following materials to niamh.mullins@mssm.edu :

  • CV

  • Cover letter

  • Names and contact details of two references

Contact: For questions about this position, please contact Dr. Niamh Mullins niamh.mullins@mssm.edu

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

  • Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential

  • Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination

  • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers

We work hard to acquire and retain the best people and to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong, and are able to professionally advance. We share the belief that all employees, regardless of job title or expertise, contribute to the patient experience and quality of patient care.

Explore more about this opportunity and how you can help us write a new chapter in our history!

Who We Are

Over 42,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve.

Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai.

The Mount Sinai Health System (MSHS) provides equal employment opportunity to all its employees and applicants for employment without unlawful discrimination on the basis of their actual or perceived race, creed, color, religion, national origin, sex, gender, gender expression, gender identity, age, disability, marital or parental status, sexual orientation, veteran, immigration, citizenship, or other protected status.

EOE including Veterans and Disabled

About Us

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

  • Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

  • Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

  • Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

EOE Minorities/Women/Disabled/Veterans

Compensation Statement

Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

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