JOB DESCRIPTION

An NIH-funded Postdoctoral Fellow position is available at the Icahn School of Medicine at Mount Sinai in New York City to participate in studies on the function of ligand activated nuclear hormone transcription factors (particularly vitamin D and glucocorticoid receptors, VDR and GR) in mammalian erythropoiesis at steady-state and under conditions of stress. We are currently investigating the possible involvement of circadian rhythm and inflammation pathways in the mechanisms by which VDR and GR regulate erythroid progenitors. These studies may lead to the identification of novel molecular targets in erythroid progenitors that can be exploited to develop new therapies for anemias and other red cell disorders. The ability to modulate ex vivo expansion or differentiation of RBC progentors in new ways would have clear clinical utility. Interested candidates must have a PhD or equivalent and should have a strong record of accomplishment and experience in molecular and cellular biology. Expertise in hematopoiesis and/or gene regulation desirable. Experience with fluorescence microscopy, flow cytometry, mouse husbandry and mammalian cell culture desirable but not essential. Applicant must be highly motivated and fluent in English, collegial and able to work independently, with at least one recent first author publication in a reputed international journal. Salary support based on research experience and accomplishments.

RESPONSIBILITIES

1. Conduct and design experiments independently under the direction of lab Principal Investigator (PI) using advanced research techniques; perform basic molecular and cellular biology methods such as basic molecular subcloning and real-time RT-PCR, mammalian cell culture, mouse husbandry, flow cytometry, and microscopy. Must be able to read, understand, and interpret scientific literature relevant to the research.

2. Report research progress to PI orally, at laboratory group meetings, and in written progress reports and maintain a current knowledge of relevant literature.

3. Maintain good written laboratory records and contact with collaborators.

4. Nurture collaborative relationships with fellow scientists within the institution, locally, nationally and internationally.

5. Summarize experimental data and assist in drafting publications under the direction of the PI. Assist the PI with publications by extracting and compiling moderate to complex research data from the relevant literature; assist in interpreting the data; write drafts of and edit manuscripts.

6. Master computer and technical skills necessary for experimental execution as well as data input and analysis.

7. Mentors and trains less experienced research staff and graduate students in research techniques and use of equipment.

8. Performs other related duties as assigned.

QUALIFICATIONS

• A Ph.D. or equivalent.

• Proficiency in molecular and cell biology (including subcloning of DNA, PCR, isolation of RNA), basic protein methods (e.g. immunoblotting), flow cytometry, and mammalian cell culture required.

• Expertise in hematopoiesis and/or gene regulation desirable.

• Expertise in computational biology (e.g. RNAseq, scRNAseq, ATACseq) desirable.

• Excellent communication skills in written and oral English are essential.

Required materials:

• brief cover letter detailing past research accomplishments and future research goals

• current CV (with bibliography)

• contact information for 3 faculty references

Non-Bargaining Unit, 031 - Hematology & Medical Oncology - ISM, Icahn School of Medicine

ABOUT US

Strength Through Diversity

The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

• Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

• Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

• Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.

Explore more about this opportunity and how you can help us write a new chapter in our history!

“About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”

EOE Minorities/Women/Disabled/Veterans

Requisition ID : 3004978