Apply for Job Job ID362155 LocationAll Other -See Job Description Job FamilyAcademic Full/Part TimeFull-Time Regular/TemporaryRegular Job Code9546 Employee ClassAcad Prof and Admin Add to Favorite Jobs Email this Job About the Job Position Summary The Babicheva lab at the Hormel Institute, University of Minnesota is seeking a highly motivated, ambitious, and talented scientist to join an enthusiastic and collaborative team of outstanding scientists. The successful applicant will hold a terminal degree from an accredited institution, in the area of cellular and molecular biology, genetics, physiology or biomedicine and have a strong track record of, and potential for, success. The applicant should have a keen research interest in endothelial-to-mesenchymal transition, cell signaling, calcium channels, gene expression regulation, or microRNA in cardiovascular research. He/she should be self-motivated in the assigned research projects, should be willing to receive training that enhances the individual's professional development and future formation of his/her own career as well as should be willing to seek for research funding. He/she should have experience of working in a research team environment and have experience of writing research reports, publications or other relevant outputs. Qualified individuals with experience in cellular and molecular biology or animal physiology in the field of pulmonary hypertension and/or heart failure are preferred. The Hormel Institute houses an equipment core including confocal and fluorescent microscopes, real time PCR, spectrophotometers, tissue processor and microtome, cryostat, and high speed and ultracentrifuges. The core facilities are further supported by dedicated facility managers responsible for training, support, and usage of equipment. Responsibilities * Conduct physiological experiments in mice and rats including assessment of hemodynamic parameters, cardiac function, isometric vessel tension in mouse and rat pulmonary arteries using wire myograph, isolated perfused lung function and lung morphology. * Conduct cellular and molecular biological experiments including Western Blot, immunofluorescence, PCR, qPCR, cell-based assays, fluorescence calcium imaging, isolation of vascular endothelial/smooth muscle cells from rodent and human lungs. * Perform data acquisition and analysis, grant and manuscript preparation, and presentation of findings at weekly lab meetings. * Maintain transgenic mouse colonies (i.e., breeding and genotyping), managing lab research records (e.g., methodological approaches, experimental records, and protocols), and maintaining a clean lab and the function of lab equipment. * Maintain a safe, clean and functional laboratory. Focus of Job Responsibilities 70% - Ongoing Research * Design and implementation of hypothesis-driven research projects. 15% - Analysis & Review * Analysis and review of generated data. * Review of scientific literature. 15% - Scientific writing Work Profile Profile 1 is expected to work primarily on-site. Your office will be located at The Hormel Institute in Austin, Minnesota. About the Lab The position is in the laboratory of Dr. Aleksandra Babicheva with overall interest in pulmonary vascular pathophysiology and right heart dysfunction, with particular emphasis on: a) pathogenic and therapeutic mechanisms of idiopathic pulmonary arterial hypertension and chronic hypoxia-induced pulmonary hypertension, as well as pulmonary hypertension associated with chronic obstructive pulmonary disease, obstructive sleep apnea, interstitial pulmonary fibrosis, sickle cell disease and scleroderma; b) cellular and molecular mechanisms of endothelial-to-mesenchymal transition and pulmonary vascular remodeling; c) regulation of Ca2+ signaling in vascular smooth muscle and endothelial cells isolated from humans and animals with pulmonary hypertension; d) role of microRNAs in the development and progression of pulmonary hypertension. A multidisciplinary a proach combining physiological, genetic, biochemical and molecular biological techniques is used to study the molecular mechanisms of vascular remodeling in pulmonary hypertension and to find new targets to develop novel therapeutically effective treatments for patients with pulmonary hypertension. Qualifications Required Qualifications * PhD, DVM, MD or equivalent) * Highly motivated * Excellent communication skills and be fluent in both spoken and written English. Preferred Qualifications * Candidates with experience in cardiovascular physiology or biochemistry/molecular biology techniques are strongly encouraged to apply About the Department The Hormel Institute is an independent biomedical research institution within the University of Minnesota's Research and Innovation Office. Established in 1942, our mission is to conduct research and provide education in the biological sciences with applications in medicine and agriculture, specifically by understanding, treating, and controlling cancer and other chronic diseases. The Hormel Institute serves as a center of technical and educational expertise for the benefit of the local community, the State of Minnesota, and beyond. We are located in the uniquely diverse rural community of Austin, MN, conveniently only 35 miles from Rochester, MN, and 100 miles (1.5 hours) south of Minneapolis/St. Paul. The Hormel Institute is committed to fostering a work environment that promotes inclusive excellence, supportive employee practices, and encourages diversity of thought that drives innovation and creativity in our science. Benefits Working at the University At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work. The University also offers a comprehensive benefits package that includes: Competitive wages, paid holidays, and generous time off Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program Low-cost medical, dental, and pharmacy plans Healthcare and dependent care flexible spending accounts University HSA contributions Disability and employer-paid life insurance Employee wellbeing program Excellent retirement plans with employer contribution Public Service Loan Forgiveness (PSLF) opportunity Financial counseling services Employee Assistance Program with eight sessions of counseling at no cost Please visit the Office of Human Resources website for more information regarding benefits. How To Apply Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume. Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section. To... For full info follow application link. The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds. The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu.