Current Employees:

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Department Specific Functions

The Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine is looking for an Associate Scientist to join the new Sylvester Proteomic Shared Resource (PSR), to apply state of the art LC-MS based methods and techniques for quantitative proteomics.

As an Associate Scientist in the PSR, you will be responsible for the maintenance and operation of a modern high resolution orbitrap mass spectrometer as well as performing detailed biochemical sample processing techniques. In addition, you will be part of a small, agile, interdisciplinary team that seeks to invent innovative methods that can be used in the development of diagnostics aimed at getting the right treatment to right patients and understanding the fundamental underpinnings of cancer biology. The individual will:

• Be the primary person responsible for the use of a new Orbitrap Ascend Tribrid LC-MS instrument for proteomic applications.

• Manage inventory of lab consumables, including ordering, receiving, and storage of supply stocks.

• Prepare protein samples from a wide range of specimen (e.g., cells, tissues, biofluids, and SDS Page gels)

• Implement of both bottom-up & top-down proteomic approaches.

• Be responsible for global proteome profiling by data-dependent (DDA) and data-independent (DIA) acquisition mass spectrometry and mass bar-codes. Detection of post-translational modifications (e.g., phosphorylation, acetylation).

• Perform relative quantification of proteins by label-free and stable-isotope labelling strategies (e.g., SILAC, TMT).

• Be responsible for structural proteomics (e.g., cross-linking, pull-down experiments).

• Conduct single-cell proteomics analysis.

• Perform intact protein analysis & MW determination.

• Use proteomics software (e.g., Proteome Discoverer, MASCOT) for data analysis.

• Be responsible for operation, maintenance, and troubleshooting of a Orbitrap Ascend Tribrid Mass Spectrometer and other laboratory equipment as needed.

• Assess experimental results and troubleshoot methods and instruments to optimize research protocols.

• Collaborate with technicians, graduate students, post-docs, PIs, the laboratory director & colleagues.

Education:

• Ph.D. in Science or Engineering (Biochemistry, Bioengineering, Biology, Chemistry, or related field)

Experience:

Minimum 5 years of relevant experience. Five years of related experience with mass spectrometry instruments which includes 2 years of experience in proteomics mass spectrometry applications.

Knowledge, Skills and Attitudes:

• Hands-on experience operating and/or maintaining LC-MS instruments and supporting equipment (including auxiliary systems such as chillers, controls, electronics, pumps, vacuum systems, etc.)

• Strong interest in handling, processing, and analyzing high-throughput datasets.

• Motivation to constantly develop skills and expertise.

• Ability to work both independently and as a team member while engaging in the organization of the proteomics core.

• Excellent analytical, communication, problem solving, and organizational skills.

• excellent written and oral communication skills.

• Established track record of publications and demonstrated ability to complete projects.

• Capability to learn complex tasks with instruction and to use experience to perform a variety of new techniques.

Preference will be given.

• Expertise in one or more of the following technical areas: quantitative proteomics, single cell proteomic analysis, global proteome profiling.

• Previous hands-on operation of Thermo Tribrid Orbitrap LC-MS Systems (e.g., Fusion, Eclipse, Ascend).

#LI-YC1

The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University Of Miami Miller School Of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

The University of Miami is an Equal Opportunity Employer - Females/Minorities/Protected Veterans/Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here (https://www.hr.miami.edu/careers/eo-ada/index.html) for additional information.

Job Status:

Full time

Employee Type:

Staff

Pay Grade:

A11

The mission of the University of Miami is to transform lives through education, research, innovation, and service. A vibrant and diverse academic and healthcare community, the University of Miami and the University of Miami Health System ("UHealth") have rapidly progressed to become one of the nation’s top research universities and academic medical centers in the nation.

The University comprises 12 schools and colleges serving undergraduate and graduate students in more than 350 majors and programs. Visit welcome.miami.edu/about-um to learn more about our points of pride.

The University ranks No. 55 on U.S. News & World Report’s 2022 Best Colleges list and ranked No. 49 in the 2022 Wall Street Journal/Times Higher Education College Rankings.

Bascom Palmer Eye Institute is ranked the #1 eye hospital in the USA and offers some of the nation's premiere eye doctors to treat every eye condition for adults. Sylvester Comprehensive Cancer, part of the Miller School of Medicine, received the prestigious National Cancer Institute designation in 2019.

The University of Miami and UHealth have also ranked among the Forbes Best Employers and Best Employers for Women on several occasions, most recently in 2022.

Transforming lives

With more than 17,000 faculty and staff, the University strives for excellence, and is driven by a powerful mission to transform and impact the lives of its students, patients, members of the community, and people across the globe.

The University is committed to fostering a culture of belonging, where everyone feels valued and has the opportunity to add value. Through values of Diversity, Integrity, Responsibility, Excellence, Compassion, Creativity, and Teamwork (DIRECCT) the U community works together to create an environment driven by purpose, excellence, community, and service.