At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Eli Lilly and Company has a research scientist opening in its Diabetes, Obesity, and Complications research organization. This position reports to the core technology and biomarkers group. The role focuses on discovering and developing novel therapeutics for type 2 diabetes, obesity, and related complications. Responsibilities include measuring endogenous metabolites and lipids to:

• Provide insights into cellular metabolism related to diabetes, obesity, and metabolic diseases, identifying new therapeutic opportunities.

• Enhance understanding of the mechanisms of action of our therapeutics.

• Phenotype human subjects, animal models, and cultured cells to discover biomarkers that predict disease incidence, severity, and progression, aiding translational research.

The team collaborates across therapeutic projects and clinical programs and partners with leading institutions and companies worldwide. We seek an experienced assay scientist with a proven track record in LC/MS/MS and GC/MS assay development and validation for small molecule quantitation. The candidate should be dedicated and highly motivated, with expertise in analyzing biofluids and tissue samples from humans and animal models. They must use meticulous research practices. Responsibilities include, but are not limited to:

• Actively engage in developing, characterizing, and selecting assays to measure endogenous biomarkers.

• Inform clinical development, target selection, and mechanism of action understanding through interpretation of assay results.

• Present research findings at scientific conferences and publish in peer-reviewed journals.

• Strategize new research opportunities for disease understanding and therapeutic intervention.

• Develop and validate targeted mass spectrometry assays for the analysis of small molecules in biological matrices.

• Acquire and process targeted-omics (metabolomics and lipidomics) data.

• Process human and animal models biological samples, as well as cell cultures and organoids, using various techniques (e.g., protein-precipitation, solid-phase extraction, dual- and three-phase extraction).

Do you have experience operating and maintaining mass spectrometers, particularly triple-quadrupoles and TOF systems, and LC/GC systems? Apply today to join the Lilly Team!

Minimum Qualifications

• PhD in biochemistry, biology, analytical chemistry or related fields

• 2-3+ years of experience in the pharma industry and/or mass spectrometry field

Additional preferences

• Demonstrated experience in processing biological samples using liquid-liquid and/or solid-phase extraction protocols.

• Proficiency in developing HILIC and reversed-phase chromatography methods for measuring small polar metabolites and lipids; MRM-based methods using triple-quadrupoles for small molecule quantitation.

• Proficiency in operating and maintaining triple quadrupole mass spectrometers and handling triple quadrupole hardware and software.

• Experience leading collaborations with project partners and outsourcing with CROs, academic institutions, and other industry partners. Essential teamwork skills to handle shared responsibilities and activities. Strong relationship-building and interaction abilities with management, peers, associates, and contractors.

• Knowledge of metabolite and lipid structures and pathways and their importance to cell biology and contribution to metabolic diseases.

• Understanding of diabetes and obesity pathophysiology and animal models.

• Experience working with bioinformatics tools for pathway analysis, biomarker discovery, and multivariate statistical analysis related to metabolites and lipids.

• Experience in metabolite tracing through use of stable isotope labeling.

• Experience developing small molecule derivatization strategies to aid LC/MS and GC/MS assays.

• Familiarity with using robotics for sample preparation.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( LillyRecruitingCompliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

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