Job Description

One of our large pharmaceutical clients in Spring House, PA is seeking a lab-based Scientist to join their growing Immunology Translational Sciences team and support the translational biomarker strategy of multiple GI disease portfolios as well as the clinical progression of innovative therapies across GI diseases. Responsibilities include:

* Deliver translational datasets to support MoA, pathway engagement assessment, PD and PK/PD-modelling for clinical development of compounds in IBD, PsO and PsA

* Deliver robust clinical biomarker datasets to support dose selection at TLR and governance meetings for the early to late stage IBD portfolio with a particular focus on Ulcerative Colitis (2024) and Crohns Disease (2025)

* Support clinical data generation, organization, and execution of laboratory logistics, quality control, initial analysis, logging, and data transfer for human serum and tissue clinical pharmacodynamic (PD) datasets by proteomic immunoassay platforms including MSD & SMC

* Support RNA extraction (QIAGEN QIAsymphony automated platform) and QC from human colonic tissue

* Support human tissue lysate generation and quantification

* Support real-time digital spatial profiling (DSP) RNA and COSMX protein analysis of clinical study FFPE tissue

* Support single cell efforts for RNA and protein through scRNAseq and DSP platforms

* Maintain compliant electronic laboratory notebook (ELN) records of all experiments

* Analysis of proteomic and transcriptomic datasets

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment regardless of their race, color, ethnicity, religion, sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military or uniformed service member status, or any other status or characteristic protected by applicable laws, regulations, and ordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or recruiting process, please send a request to HR@insightglobal.com .

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Skills and Requirements

* A minimum of a B.S. Degree in Biology or related field of study

* 2+ years of experience generating and prepping mammalian tissue for RNA and protein in a lab setting

* 2+ years of experience with developing and executing immunoassays, specifically MSD (Meso Scale Discovery) platform

* Strong attention to detail * Prior experience with Spatial biology techniques and analysis (DSP Nanostring, MIBI IonPath, IMC Fluidigm ect.)

* Prior experience in translational research, including biomarker analysis, patient stratification, and diagnostic approaches null

We are a company committed to creating diverse and inclusive environments where people can bring their full, authentic selves to work every day. We are an equal employment opportunity/affirmative action employer that believes everyone matters. Qualified candidates will receive consideration for employment without regard to race, color, ethnicity, religion,sex (including pregnancy), sexual orientation, gender identity and expression, marital status, national origin, ancestry, genetic factors, age, disability, protected veteran status, military oruniformed service member status, or any other status or characteristic protected by applicable laws, regulations, andordinances. If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to HR@insightglobal.com.